Diversity/Target Oriented Synthesis of Complex Molecules via Multi-Component Reactions

Diversity/Target Oriented Synthesis of Complex Molecules via Multi-Component Reactions

The rapid generation of diverse sets of complex molecules can be achieved by employing diversity oriented synthetic strategies in combination with so called complexity generating reactions. Multicomponent reactions (MCRs) have been emerged as an extremely powerful tool in combinatorial chemistry and drug discovery, since it offers significant advantages over conventional linear step syntheses, ...

Application of Water for Synthesis of Cyclopentadienes via Multi-component Reactions of N-methyl imidazole

A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparati...

One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

application of water for synthesis of cyclopentadienes via multi-component reactions of n-methyl imidazole

Synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) via multi-component reactions by using silica-bonded sulfamic acid derivatives

The one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) by tandem Knoevenagel-Michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded N-propylpiperazine sulfamic acid (SBPPSA) as a recyclable solid acid catalyst was reported. SBPPSA showed much the same efficiency when used in consecutive reaction runs.